Avanced imaging of coronary vasculitis associated with Kasaki disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: SUDA KENJI 久留米大学, 医学部, 教授 (10399173)
• Co-Investigator(Kenkyū-buntansha): 田原 宣広 久留米大学, 医学部, 准教授 (10320186) ; 工藤 嘉公 久留米大学, 医学部, 助教 (10368920) ; 吉本 裕良 久留米大学, 医学部, 助教 (10624463) ; 岸本 慎太郎 久留米大学, 医学部, 助教 (60648632)
• Research Collaborator: KISHIMOTO Shintaro 久留米大学, 医学部, 助教 (60648632) ; YOSHIMOTO Hironaga 久留米大学, 医学部, 助教 (10624463)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 川崎病 / 冠状動脈瘤 / ポジトロン断層診断法

Outline of Final Research Achievements

Kawasaki disease is the most common acquired heart disease in the developed countries and its incidence rate is the highest in Japan where more than 15,000 patients are suffered every year. The most important complication of this disease is coronary aneurysm formation that can progress to intimal thickening and calcification leading to coronary stenosis and ischemic heart disease.
In this project, we compared coronary wall uptake of 18-fluorodeoxyglucose using positron emission tomography combined with X-ray computed tomography between patients left with persistent coronary aneurysms and those whose coronary aneurysms disappeared with time and found that patients with persistent coronary aneurysms showed significantly higher coronary wall uptake of 18-fluorodeoxyglucose suggesting active inflammatory process at coronary wall in these patients.We have just started comparison of magnetic resonance images with positoron emission tomographic images.

Free Research Field

小児科