Development of oxygen-enhanced cardiac MRI

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Kawanami Satoshi 九州大学, 医学研究院, 助教 (50330999)
• Co-Investigator(Kenkyū-buntansha): 神谷 武志 九州大学, 大学病院, 助教 (20419534) ; 山之内 寅彦 九州大学, 大学病院, 医員 (40748034) ; 長尾 充展 九州大学, 医学研究院, 准教授 (60533081) ; 藪内 英剛 九州大学, 医学研究院, 教授 (70380623) ; 本田 浩 九州大学, 大学病院, 教授 (90145433)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: MRI / 心臓 / 酸素

Outline of Final Research Achievements

We developed the novel oxygen-enhanced MRI protocol, and investigated the utility of T2*-weighted cardiac MRI, visualizing the difference of signals during normoxia (T2*air) and hyperoxia (T2*oxy) in cases with normal, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Oxygen-enhanced T2* cardiac magnetic resonance (CMR) showed the different delta T2* (T2*oxy - T2* air), reflecting myocardial blood-oxygen dependent (BOLD) effect. T2* was stable or shortened in HCM and normal due to vasoconstriction or hypo-perfusion, and in congestive heart failure (CHF) and DCM, respectively.

Free Research Field

放射線診断学