Study on the establishment of myelin-specific PET imaging technology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Matsuda Hiroshi 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
• Co-Investigator(Kenkyū-buntansha): 宿里 充穗 昭和薬科大学, 薬学部, 助教 (20525571) ; 加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: PET / ミエリン

Outline of Final Research Achievements

In this study, we have been investigating using 11C-MeDAS, which has already been reported as a myelin-specific PET probe, for the diagnosis of demyelinating diseases such as multiple sclerosis using model animals. Experimental autoimmune encephalomyelitis rats were used to study 11C-MeDAS PET experiments and connectivity using brain slices, but no change in accumulation in demyelinating lesions was observed. As a factor that 11 C - MeDAS did not show sufficient specificity and quantitativeness, 11 C - MeDAS was chemically unstable under radiolabeling conditions, and it was thought that a radiolytic product was easily generated. We began to develop a novel diamine tracer that converted the stilbene skeleton, which is considered to be one of causes of destabilization, to a structure expected to be stable under radiolabeling conditions.

Free Research Field

放射線科学