Efficacy of prophylactic functional foods for amelioration of radiation enteropathy and its metabolism

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Okamoto Yoshiaki 神戸大学, 医学研究科, 非常勤講師 (20362791)
• Co-Investigator(Kenkyū-buntansha): 赤坂 浩亮 神戸大学, 医学部附属病院, 特命助教 (20707161) ; 佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267) ; 江島 泰生 獨協医科大学, 医学部, 講師 (70423233) ; 椋本 成俊 神戸大学, 医学部附属病院, 特命技術員 (70634278) ; 吉田 賢史 神戸大学, 医学部附属病院, 特命准教授 (80351906)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: プロフィラクテック食品 / 放射線治療 / 消化管

Outline of Final Research Achievements

Effective methods to ameliorate radiation enteropathy have not been developed. To address this issue, reduced CoQ10 was investigated as a potential radioprotective, functional dietary supplement.Reduced CoQ10 was accumulated in all sections of the intestine in supplemented mice. Supplementation with CoQ10 was contributed to suppressing production of reactive oxygen species and inhibiting apoptosis in the crypts, leading to preservation of villi structures after the irradiation. Metabomic analyses were performed. Reduced CoQ10 seemed to be a candidate for amelioration of radiation enteropathy

Free Research Field

放射線腫瘍学