Near infrared fluorescence light imaging for para-aortic lymph node targeting in hepatobiliary malignancies

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hokkaido University
• Principal Investigator: Noji Takehiro 北海道大学, 大学病院, 助教 (10739296)
• Co-Investigator(Kenkyū-buntansha): 平野 聡 北海道大学, 医学研究院, 教授 (50322813) ; 中村 透 北海道大学, 医学研究院, 助教 (70645796) ; 岡村 圭祐 北海道大学, 大学病院, 助教 (90724401)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: センチネルリンパ節転移診断 / 光線力学的診断

Outline of Final Research Achievements

Methods: Sixty-two patients with hepato-pancreatic-biliary malignancies were enrolled in this study. We optimized the dose of ICG in the first 15 patients, and evaluated the detection rate for RLN and PAN in the remaining 47.
Results: The optimal administered dose of ICG for detecting fluorescent signals in PAN was 5 mg/mL. However we could detect RLN and PAN fluorescence in only 29 of 42 patients injected with this dose.Conclusion: 5 mg/ml of ICG to visualize lymphatic flow from the hepatoduodenal ligament to PAN using ICG-NIR imaging was failed. Detection rate of RLN and PAN were 69%, respectively. Further improvement for this procedure will be necessary for clinical application.

Free Research Field

消化器外科学