Identification of molecular targets to predict postoperative outcomes in patients with neuroendocrine cell carcinoma of the esophagus

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10089
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Toyama
• Principal Investigator: Kojima Hirohumi 富山大学, 大学院医学薬学研究部(医学), 助教 (60750114)
• Co-Investigator(Kenkyū-buntansha): 奥村 知之 富山大学, 附属病院, 講師 (10533523)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: NEC / esophagus / Esophageal cancer / miRNA

Outline of Final Research Achievements

Background: Neuroendocrine cell carcinoma of the esophagus (ENEC) is a rare but very aggressive disease with poor prognosis. The aim of this study was to identify a molecular signature to predict postoperative outcomes in patients with ENEC. Methods: Expression of microRNA was detected in surgically-removed ENEC tumors using microarrays. A SCCE cell line (TYUC-1) was established to investigate the biological role of differentially expressed microRNAs. Results: Hierarchical clustering of microRNA expression revealed two discrete clusters that were identical to the cases with rapid tumor relapse and the cases with long-term survival, respectively. Migration of TYUC-1 was significantly inhibited by downregulation of miR-625. Conclusion: The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with ENEC.

Free Research Field

消化器外科学