Establishment of epigenome panel for identification of lymph node metastasis in gastric cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Yasuda Hiromi 三重大学, 医学部附属病院, 助教 (60586767)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学部附属病院, 講師 (00422824) ; 毛利 靖彦 三重大学, 医学系研究科, 客員准教授 (70345974) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胃癌 / リンパ節転移 / 遠隔転移 / microRNA / DNAメチル化

Outline of Final Research Achievements

The aim of this study was to identify clinically relevant epigenetic markers for presence of lymph node metastasis in gastric cancer. Array-based comprehensive analysis demosntrated that miR-4286 expression was significantly increased with disease development and lymph node metastasis in gastric cancer. Although we could not identify approproate candidates of methylated DNA, gene expression analysis demonstrated that increased ANGPTL2 expression was depply involved in lymph node metastasis and poor prognosis in gastric cancer patients.

Free Research Field

悪性腫瘍