Development of a ghrelin supportive therapy for patients with high invasive surgery and highly morbidity risks

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10099
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nagoya City University (2017); Osaka University (2015-2016)
• Principal Investigator: Takiguchi Shuji 名古屋市立大学, 大学院医学研究科, 教授 (00301268)
• Co-Investigator(Kenkyū-buntansha): 宮崎 安弘 大阪大学, 医学系研究科, 助教 (00571390) ; 黒川 幸典 大阪大学, 医学系研究科, 助教 (10470197) ; 新野 直樹 大阪大学, 医学部附属病院, 医員 (10724122) ; 土岐 祐一郎 大阪大学, 医学系研究科, 教授 (20291445) ; 山崎 誠 大阪大学, 医学系研究科, 准教授 (50444518) ; 高橋 剛 大阪大学, 医学部附属病院, その他 (50452389) ; 柳本 喜智 大阪大学, 医学部附属病院, 医員 (70645085) ; 宮田 博志 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (80362713) ; 牧野 知紀 大阪大学, 医学部附属病院, その他 (80528620)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: グレリン / 外科侵襲 / 胃癌

Outline of Final Research Achievements

Preoperative and postoperative ghrelin change after pancreatoduodenectomy (PD) and distal pancreatectomy were examined in this study. Our research revealed less change of ghrelin concentration in plasma than gastrectomy PD patients with severe morbidity, which corresponded to over Grade 3 complications according to Clavien-Dindo classification, showed a higher reduction rate of ghrelin level at postoperative day 1 compared to preoperative level than other patients. Conclusion of this study was that the individual ghrelin ration relative to preoperative value (IGR) on POD 1 after PD may be a useful marker for predicting postoperative complications.
In summary, concentration measurement of plasma ghrelin level may be useful and ghrelin administration for geriatric patients were safe as a supportive therapy in the multidisciplinary approach for gastrointestinal cancer patients.

Free Research Field

消化器外科学