2017 Fiscal Year Final Research Report
Identification of the Warburg effect-associated microRNAs and those targeting genes and clinical application of those
| Project/Area Number |
15K10120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
赤尾 幸博 岐阜大学, 大学院連合創薬医療情報研究科, 教授 (00222505)
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| Research Collaborator |
TANIGUCHI Kohei 大阪医科大学, 医学部, 助教 (70779686)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | microRNA / Warburg 効果 / PTBP1 / RNA helicase / MYC |
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| Outline of Final Research Achievements |
In this project, we found that cancer-specific energy metabolism (Warburg effect) is regulated by several organ-specific microRNAs (miRNAs). Especially, MIR122, 137 and 206 had organ specificity and regulated Warburg effect-associated genes, i.e., PKM or PTBP1. Also, we indicated that PTBP1 is novel oncogene in colorectal tumors and that up-regulation of PTBP1 was induced by dysregulation of the MIR1 and 133b. Moreover, we partially clarified the functions of the Warburg effect-associated genes in chemo-resistant cancer cells. Namely, PKM2 was dominant in cancer cells, but in chemo-resistant cancer cells, PKM1 was re-up-regulated through the reverse shift of PKM isoforms.
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| Free Research Field |
消化器外科
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