Comprehensive analysis to elucidate the mechanism of cancer metabolism in esophageal squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Watanabe Masayuki 公益財団法人がん研究会, 有明病院 消化器外科, 部長 (80254639)
• Co-Investigator(Kenkyū-buntansha): 森 誠一 公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, プロジェクトリーダー (10334814) ; 馬場 祥史 熊本大学, 医学部附属病院, 特任講師 (20599708) ; 澤山 浩 熊本大学, 医学部附属病院, 非常勤診療医師 (40594875) ; 今村 裕 公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (70583045)
• Research Collaborator: Haraguchi Ikumi 公益財団法人がん研究会, がんプレシジョン医療研究センター がんモデル開発グループ, 特任研究助手 ; Ogata Yoko 熊本大学, 大学院生命科学研究部 消化器外科学, 技術補佐員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食道癌 / 代謝 / 脂肪

Outline of Final Research Achievements

In this study, we have collected omental fat, extracting total RNA, and then submitted those to microarray analysis [high-BMI cases (BMI more than 25, N=3) vs. normal-BMI cases (BMI around 20, N=3)], in the patient with esophageal squamous cell carcinoma who underwernt curative resection in our institution. Pathway analysis revealed that complementary activation pathway was significantly upregulated in the high-BMI cases (N=3), compared to the normal-BMI cases (P=0.0028). Especially, we observed significantly overexpression of C3 and C4 genes in the high-BMI cases. Our results suggest that in obese patients with esophageal squamous cell carcinoma, complements C3/C4 were highly produced in omental fat, activate classical pathyway of complement at the tumor microenvironments.

Free Research Field

食道癌