• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Comprehensive analysis to elucidate the mechanism of cancer metabolism in esophageal squamous cell carcinoma

Research Project

  • PDF
Project/Area Number 15K10122
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

Watanabe Masayuki  公益財団法人がん研究会, 有明病院 消化器外科, 部長 (80254639)

Co-Investigator(Kenkyū-buntansha) 森 誠一  公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, プロジェクトリーダー (10334814)
馬場 祥史  熊本大学, 医学部附属病院, 特任講師 (20599708)
澤山 浩  熊本大学, 医学部附属病院, 非常勤診療医師 (40594875)
今村 裕  公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (70583045)
Research Collaborator Haraguchi Ikumi  公益財団法人がん研究会, がんプレシジョン医療研究センター がんモデル開発グループ, 特任研究助手
Ogata Yoko  熊本大学, 大学院生命科学研究部 消化器外科学, 技術補佐員
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords食道癌 / 代謝 / 脂肪
Outline of Final Research Achievements

In this study, we have collected omental fat, extracting total RNA, and then submitted those to microarray analysis [high-BMI cases (BMI more than 25, N=3) vs. normal-BMI cases (BMI around 20, N=3)], in the patient with esophageal squamous cell carcinoma who underwernt curative resection in our institution. Pathway analysis revealed that complementary activation pathway was significantly upregulated in the high-BMI cases (N=3), compared to the normal-BMI cases (P=0.0028). Especially, we observed significantly overexpression of C3 and C4 genes in the high-BMI cases. Our results suggest that in obese patients with esophageal squamous cell carcinoma, complements C3/C4 were highly produced in omental fat, activate classical pathyway of complement at the tumor microenvironments.

Free Research Field

食道癌

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi