Clinical application to significance and growth control of the chromosome instability in carcinogenesis, the progress of gastrointestinal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University (2016-2017); National Hospital Organization, Kyushu Cancer Center (2015)
• Principal Investigator: KAWANO Hiroyuki 九州大学, 医学研究院, 共同研究員 (70596668)
• Co-Investigator(Kenkyū-buntansha): 江頭 明典 独立行政法人国立病院機構別府医療センター(臨床研究部), 臨床研究部, その他 (00419524) ; 藤 也寸志 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 院長 (20217459) ; 森田 勝 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (30294937) ; 沖 英次 九州大学, 大学病院, 助教 (70380392) ; 佐伯 浩司 九州大学, 大学病院, 助教 (80325448)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食道癌 / メチル化 / FANCJ

Outline of Final Research Achievements

In multiple esophageal cancer and multiple Lugol-voiding lesion of esophagus, the LINE-1 methylation in the esophageal nomal mucosa significantly decreased. We suggest that the genome-wide hypomethylation was wide participated in outbreak of many carcinogenesis. In addition, methylation abnormality of various chemokines and in cancer of the esophagus was associated with genome-wide hypomethylation.
An effect of the preoperation chemotherapy (5FU+CDDP) was high in esophageal cancer that had a low FANCJ expression, and the group that enforced 5FU+CDDP after surgery in a low FANCJ expression had a better prognosis than surgery alone group. Furthermore, in the patients of esophageal cancer that gave chemotherapy after surgery, the low FANCJ expression group significantly had a better prognosis than overexpression group. The expression of FANCJ can become a useful marker as effect measurement of the chemotherapy.

Free Research Field

総合生物