Comprehensive analysis of microRNAs associated with peritoneal dissemination of colorectal cancer and treatment strategy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Fujikawa Hiroyuki 三重大学, 医学部附属病院, 助教 (40616091)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学部附属病院, 講師 (00422824) ; 井上 靖浩 三重大学, 医学系研究科, 客員准教授 (20324535) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大腸癌 / 腹膜播種 / microRNA

Outline of Final Research Achievements

To identify miRNA biomakers for peritoneal metastasis in colorectal cancer and to clarify the funtional mechanism of these miRNAs for development of peritoneal metastasis, we performed array-based comprehesive analysis. From this result, we demonstrated that serum miR-1290 was significantly increased in CRC patients compared to healthy volunteers, and increased serum miR-1290 was significantly correlated with recurrence and poor survival in CRC. Especially, serum miR-1290 was significantly increased in CRC patients harboring peritoneal metastasis, and suggested that serum miR-1290 might be used as a predictive biomarker for peritoneal metastasis in CRC patients.

Free Research Field

Colorectal cancer