Comprehensive analyses of DNA methylation for the development of pouchitis after surgery in patients with ulcerative colitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Kawamura Mikio 三重大学, 医学系研究科, リサーチアソシエイト (00722589)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学部附属病院, 講師 (00422824) ; 大北 喜基 三重大学, 医学部附属病院, 助教 (20378342) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026) ; 荒木 俊光 三重大学, 医学系研究科, 准教授 (70343217)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 回腸嚢炎 / 潰瘍性大腸炎 / DNA methylation

Outline of Final Research Achievements

Comprehensive microRNA and mRNA expression patterns related to pouchitis were analyzed using ileal mucosa at the time of colectomy. Interferon gamma and FK506 binding protein mRNA levels in ileal mucosa could be predictive for the onset of pouchitis after surgery.
Using epigenomic analysis, we found specific micro RNAs to be methylated in rectal mucosal samples from patients with ulcerative colitis associated cancer, and could be used to identify patients with ulcerative colitis at high risk for developing neoplasia.

Free Research Field

消化器外科