2017 Fiscal Year Final Research Report
Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer.
Project/Area Number |
15K10184
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Hiroshima University |
Principal Investigator |
Murakami Yoshiaki 広島大学, 医歯薬保健学研究科(医), 准教授 (10263683)
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Co-Investigator(Kenkyū-buntansha) |
橋本 泰司 広島大学, 学内共同利用施設等, その他 (50423380)
上村 健一郎 広島大学, 医歯薬保健学研究科(医), 講師 (60379873)
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Research Collaborator |
HADANO Naoto 広島大学, 大学院生
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 膵癌 / バイオマーカー / K-ras変異 / cell free DNA |
Outline of Final Research Achievements |
We used droplet digital polymerase chain reaction to detect rare mutant tumour-derived KRAS genes in plasma cell-free DNA (cfDNA) as ctDNA. Samples were collected from 105 patients who underwent pancreatoduodenectomy for PDAC at a single institution. Overall survival (OS) was analysed according to the presence of ctDNA.Among the 105 cases, ctDNA was detected in 33 (31%) plasma samples. The median OS durations were 13.6 months for patients with ctDNA (ctDNA+) and 27.6 months for patients without ctDNA. Patients who were ctDNA+ had a significantly poorer prognosis with respect to OS (P<0.0001).Our findings suggested that the presence of ctDNA in plasma samples could be an important and powerful predictor of poor survival in patients with PDAC. Accordingly, ctDNA detection might be a promising approach with respect to PDAC treatment.
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Free Research Field |
膵癌 バイオマーカー
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