Relationship between stromal cells and pancreatic cancer cells in metastasis and dissemination

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: MORIYAMA Taiki 九州大学, 大学病院, 准教授 (70586859)
• Co-Investigator(Kenkyū-buntansha): 藤田 逸人 九州大学, 医学研究院, 助教 (40611281) ; 坂井 寛 九州大学, 医学研究院, 共同研究員 (80611665) ; 水元 一博 九州大学, 大学病院, 准教授 (90253418) ; 大内田 研宙 九州大学, 大学病院, 講師 (20452708)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膵癌 / 間質細胞 / 膵星細胞 / 腹膜中皮細胞 / 湿潤・転移 / 腹膜播種 / リモデリング

Outline of Final Research Achievements

Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180. Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination by cancer interstitial interaction and microenvironment alteration. Furthermore, we identified autophagy was involved in the activation of pancreatic stellate cells. In the mouse model, suppression of autophagy of pancreatic stellate cells reduced tumor development and metastasis. From these results, we clarified the possibility of a new treatment targeting stroma.

Free Research Field

医歯薬学