Elucidation of acquired von Willebrand syndrome in cases with mechanical circulation support

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Tohoku University
• Principal Investigator: Fujiwara Hidenori 東北大学, 医学系研究科, 非常勤講師 (20747117)
• Co-Investigator(Kenkyū-buntansha): 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 秋山 正年 東北大学, 大学病院, 講師 (80526450) ; 河津 聡 東北大学, 大学病院, 助教 (80633685)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: von Willebrand factor / 後天性von Willebrand症候群 / 補助人工心臓 / 出血合併症 / vWF large multimer Index / 消化管出血 / Shear stress / ADAMTS13

Outline of Final Research Achievements

In this study, we first established methodology of a hematological severity of acquired von Willebrand syndrome. Using this, we examined 41 patients after implanted left ventricular assist device, clarified the relationship between the hematological severity of acquired von Willebrand syndrome and gastrointestinal bleeding. Another purpose of this study was to develop the method to predict hematological severity of acquired von Willebrand syndrome. We newly developed a shear-stressor for blood and established a method for predicting the hematological severity of acquired von Willebrand syndrome, and filed a patent application.

Free Research Field

医学