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2017 Fiscal Year Final Research Report

Overcoming ischemic cardiomyopathy by angiogenic drugs

Research Project

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Project/Area Number 15K10214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionOsaka University

Principal Investigator

Ueno Takayoshi  大阪大学, 医学系研究科, 寄附講座准教授 (60437316)

Co-Investigator(Kenkyū-buntansha) 宮川 繁  大阪大学, 医学系研究科, 特任教授(常勤) (70544237)
福嶌 五月  国立研究開発法人国立循環器病研究センター, 病院, 医長 (80596867)
秦 広樹  大阪大学, 医学系研究科, 講師 (80638198)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords心筋再生 / プロスタサイクリン作動薬 / 有茎大網 / 心筋血流量 / 心筋血管抵抗
Outline of Final Research Achievements

We hypothesized that therapeutic efficacy may be augmented by a combination of placing a sheet immersed in ONO-1301SR, a slow-release synthetic prostacyclin agonist-inducing multiproangiogenic cytokines, over the left ventricle and a pedicled omental flap in a chronic myocardial infarct heart.
In conclusions,ONO-1301SR combined with a pedicled omental flap therapy synergistically promoted myocardial angiogenesis,leading to cardiac functional recovery in a porcine chronic MI model.This cell-free combination therapy shows promise as an effective treatment for enhancement of myocardial angiogenesis in a chronic MI heart.

Free Research Field

心臓血管外科学

URL: 

Published: 2019-03-29  

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