Development of alleviation of rejection by autologous cardiogenic stem cell from explanted heart

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Okayama University
• Principal Investigator: Arai Sadahiko 岡山大学, 医歯薬学総合研究科, 講師 (50345617)
• Co-Investigator(Renkei-kenkyūsha): OH Hidemasa 岡山大学病院, 新医療研究開発センター, 教授 (50372579)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 再生医療 / 心臓移植 / 心臓血管外科

Outline of Final Research Achievements

We evaluated effect of autologous cardiogenic stem cell by heterotopic cardiac transplantation model in rat. We observed tendency of prolongation of graft survival and improved cardiac function in data. Further evaluation and statistic analysis are on-going. We analyzed origin of cardiac cell in myocardium. We found mixed existence of myocardial cell and cardiogenic stem cell. At this moment we cannot conclude whether the effect of cardiogenic stem cell is based on regeneration and proliferation of myocardium from stem cell or paracrine function from stem cell by endocrine hormone and chemical mediators and so on. Thus we continue further morphological evaluation of myocardial tissue of transplanted graft, we also considering further evaluations based on hormone/ chmical mediator analysis.

Free Research Field

心臓血管外科