2017 Fiscal Year Final Research Report
Development of the therapy fot AAA induced by mechanichal stress
| Project/Area Number |
15K10242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 大動脈瘤 / ペリオスチン / メカニカルストレス |
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| Outline of Final Research Achievements |
The development of the medical therapy to restrain pathologic progress in the state that the aortic aneurysm has only the surgical treatment. We analyze a mouse aortic aneurysm model cyclopedically; and periostin gene (confirmed that PN) increased in response to mechanical stress.) Therefore I confirmed that PN restraint led to improvement of the AAA using two kinds of AAA models and PNKO mice. In addition, I confirmed that blood PN rose by smoking by the analysis of the blood sample before and after the clinical smoking cessation. Possibility of the PN restraint was suggested as a new target of the AAA.
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| Free Research Field |
難治性循環器疾患の治療
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