Significance of lung caner stem cell-related gene and lung stem cell-related genes in primary non small cell lung carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyushu University
• Principal Investigator: HARO Akira 九州大学, 医学研究院, 共同研究員 (90546558)
• Co-Investigator(Kenkyū-buntansha): 田川 哲三 九州大学, 大学病院, その他 (90419557)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺癌幹細胞 / 肺組織幹細胞

Outline of Final Research Achievements

The object of this study is to investigate the significance of lung cancer stem cell-associated gene and lung stem cell-associated genes.[1] The lung cancer stem cell-associated gene CD133 was a significant poor prognostic factor in both all-over survival and disease-free survival, expectively p=0.0001 and p=0.0378.
[2] Lung Stem cell associated genes. (1 ) Notch1 Protein was expressed significantly in smaller-sized tumor (p<0.003). Furtheremore, Notch1 had significant relations with female and EGFR mutation(p=0.031 p=0.002, respectively). Notch 1 was not a prognostic factor. (2) Yap protein was slightly more in adenocarcinoma, but it was not significant. Yap was not a prognostic factor.
[Concludions] CD133 was a poor prognostic factor. Notch1 and YAP was not significant prognostic factor, but it needs to be investigated from the disease-free survival or anticancer drug resistance.

Free Research Field

肺癌