Comprehensive analysis of lung adenocarcinoma focus on the recurrence and response to chemotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Fukushima Medical University (2016-2017); National Cancer Center Japan (2015)
• Principal Investigator: Saito Motonobu 福島県立医科大学, 医学部, 講師 (90611749)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺腺癌 / ドライバー遺伝子 / 遺伝子融合

Outline of Final Research Achievements

We performed a comprehensive genetic analysis for lung adenocarcinomas (LADC) and found that the driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling. On the other hand, pan-negative LADCs appear to develop from a large number of gene mutations, including mutations in TP53 and other cancer-related genes. Next, we have compared the frequency of each driver genes between Japan and US cohort. EGFR mutations are more prevalent in Japanese patients, whereas KRAS and BRAF mutations are more prevalent in the US. To date, the molecularly targeted drugs for KRAS mutations have not developed yet, targeted therapy have not adapted the patients with LADC in the US. In conclusion, the information of driver genes will aid in the selection of appropriate targeted therapy.

Free Research Field

ゲノム生物学