2017 Fiscal Year Final Research Report
Relashionship between cognitive function and amino acid dynamics in the brain using positron emission tomography in patients udergoing carotid endarterectomy
| Project/Area Number |
15K10313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Research Collaborator |
YOSHIDA Kenji
KOBAYASHI Masakazu
FUJIWARA Shunrou
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 頚動脈内膜剥離術 / 認知機能 / 神経受容体 / アミノ酸代謝 |
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| Outline of Final Research Achievements |
Uptakes of three radiotracers for amino acid on positron emission tomography were significantly more greatly increased in patients with postoperative cognitive improvement than in those without. In particular, uptake changes of 18F-Fluoro-α-methyl-L-Tyrosine mostly correlated with degree of postoperative cognitive improvement. These findings suggested that an increase in functional activity of neuroreceptor is associated with cognitive improvement after carotid ebdarterectomy and that an increase in amino acid metabolism is associated with an increase in functional activity of neuroreceptor.
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| Free Research Field |
脳神経外科
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