Elucidation of radiation sensitization mechanism by hyperbaric oxygen therapy.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: University of the Ryukyus
• Principal Investigator: Hideki Nagamine 琉球大学, 医学部, 助教 (30573331)
• Co-Investigator(Kenkyū-buntansha): 片桐 千秋 琉球大学, 医学(系)研究科(研究院), 助教 (00443664) ; 石内 勝吾 琉球大学, 医学(系)研究科(研究院), 教授 (10312878) ; 菅原 健一 琉球大学, 医学部附属病院, 講師 (50375573) ; 渡邉 孝 宮崎大学, 医学部, 講師 (90573337)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: グリオブラストーマ / 高気圧酸素療法 / 放射線照射 / 低酸素

Outline of Final Research Achievements

Hyperbaric oxygen treatment combined with radiation therapy improve radiation sensitivity on glioblastoma in our clinical data. In this study, we developed a xenograft animal model and investigated the influence of gene expression in the tumor contrarily in the radiation alone group and the hyperbaric oxygen therapy group on radiation sensitivity. Tet-on expression-inducing strain of tumor cell line U87-MG cells was constructed and induction of gene X expression after spheroid formation was also positive for pimonidazole, a hypoxic marker. It was suggested that gene X contributes to enhancement of radiosensitivity rather than involvement in hypoxia.

Free Research Field

脳神経外科