2017 Fiscal Year Final Research Report
Novel methylation markers of glioma and glioma stemcell and their application to individualized medicine
| Project/Area Number |
15K10342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANE Motoo 杏林大学, 医学部, 教授 (60327468)
SAITO Kuniaki 杏林大学, 医学部, 助教 (50446564)
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| Research Collaborator |
SHIMIZU Saki 杏林大学, 医学部, 実験助手
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 神経膠腫 / メチル化 / パイロシークエンス / MGMT / IGFBP2 / 幹細胞 |
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| Outline of Final Research Achievements |
We performed methylation analysis of glioma and glioma stemcell using pyrosequencing to find novel methylation marker. Methylation of MGMT, known prognostic factor, and IGFBP2 were analyzed. IGFBP2 methylation revealed to predict glioma grade. Furthermore, methylation level of IGFBP2 was significantly lower in glioma stemcell, indicating that IGFBP2 was associated with stemness and could be therapeutic target of glioma.
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| Free Research Field |
悪性脳腫瘍
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