2017 Fiscal Year Final Research Report
Elucidation of the M2 macrophage in brain metastases from lung cancer
| Project/Area Number |
15K10347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤田 貢 近畿大学, 医学部, 准教授 (40609997)
中田 晋 京都薬科大学, 薬学部, 准教授 (80590695)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 転移性脳腫瘍 / M2マクロファージ / 肺がん |
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| Outline of Final Research Achievements |
It was recognized that the immune system mainly on the M2 macrophage participated in mechanism of the metastasis to brain onset in the lung cancer. Furthermore, I was able to identify the gene cluster which could become the treatment target of this M2 macrophage in microarray analysis. In addition, this immunoresponse proved that the metabolism product which intestinal bacteria produced participated. The possibility that a new treatment strategy to prevent metastasis to brain was provided was suggested in future.
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| Free Research Field |
脳腫瘍
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