New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: Sugiyama Shinichiro 東北大学, 医学系研究科, 非常勤講師 (30623152)
• Co-Investigator(Kenkyū-buntansha): 遠藤 俊毅 東北大学, 医学系研究科, 非常勤講師 (00535370) ; 新妻 邦泰 東北大学, 大学病院, 講師 (10643330) ; 船本 健一 東北大学, 学際科学フロンティア研究所, 准教授 (70451630) ; 坂田 洋之 東北大学, 医学系研究科, 非常勤講師 (80722305)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: drug delivery / cell therapy

Outline of Final Research Achievements

Spinal cord injury has dismal prognosis even in this modern era. Convection-enhanced delivery (CED) is a method for distributing small and large molecules locally in the interstitial space of the spinal cord. Delivering these molecules to the spinal cord is otherwise difficult due to the blood spinal cord barrier. This study revealed that regional infusion of drugs into the spinal cord via CED is a promising strategy for treating spinal cord injury. In addition, we investigated the safety and efficacy of stem cell transplantation (multilineage-differentiating stress enduring cell (Muse cell) transplantation) in spinal cord injury.

Free Research Field

神経外科学