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2018 Fiscal Year Annual Research Report

The efficacy of deep brain stimulation on gross motor and precise finger motor in monkey Parkinson's disease models, a PET study

Research Project

Project/Area Number 15K10358
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

浅川 哲也  浜松医科大学, 医学部, 特任助教 (00469917)

Co-Investigator(Kenkyū-buntansha) 杉山 憲嗣  浜松医科大学, 医学部, 准教授 (00235904)
鈴木 勝昭  浜松医科大学, 医学部, 准教授 (00285040) [Withdrawn]
Project Period (FY) 2015-04-01 – 2019-03-31
Keywordsパーキンソン氏病 / 行動判定テスト / サルモデル / 脳深部電気刺激術 / PET / 粗大運動 / 微細運動 / 脳血流
Outline of Annual Research Achievements

今年度は既定の研究計画により、以下の研究を行った。
(1)我々は提案した行動判定テストによるOMS原則[Oはobjectification(客観化)を意味し、なるべく客観的なテストを開発、使用すること;Mはmulti-purpose(多目的化)]を活用し、小児のmovement disorders(PMDs)における行動判定テストのreview論文及び最新のIT技術を利用し、新規の行動判定テストについての論文を発表した。(2)分子イメージング研究のデータの解析は終了し、論文を作成中。(3)研究分担者の野崎先生と一緒に、患者と動物の微細運動と粗大運動の研究を続けている。患者の部分データを論文発表できた。現在、この研究の後続研究(18K08991)を同時にサルと人間の粗大運動と微細運動のデータ解析を進行中。(4)それ以外、論文リストによる他の研究もサポートした。これらの成果は、DBSの機序及びパーキンソン氏病の行動判定テストに知見を提供できる。

  • Research Products

    (17 results)

All 2019 2018

All Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (6 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results)

  • [Journal Article] An in vitro validation of the therapeutic effects of Tougu Xiaotong capsule on tunicamycin-treated chondrocytes2019

    • Author(s)
      Liang W, Li X, Hu L, Ding S, Kang J, Shen J, Zheng C, Li C, Ye H, Asakawa T*
    • Journal Title

      J Ethnopharmacol

      Volume: 229 Pages: 215-221

    • DOI

      https://doi.org/10.1016/j.jep.2018.10.022

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Can the Latest Computerized Technologies Revolutionize Conventional Assessment Tools and Therapies for a Neurological Disease? The Example of Parkinson’s Disease2019

    • Author(s)
      Asakawa T*, Sugiyama K, Nozaki T, Sameshima T, Kobayashi S, Wang L, Hong Z, Chen S, Li C, Namba
    • Journal Title

      Neurol Med Chir

      Volume: 59 Pages: 69-78

    • DOI

      https://doi.org/10.2176/nmc.ra.2018-0045

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice2019

    • Author(s)
      Jiang B, Zheng S, An L, Guo, J, Asakawa T*
    • Journal Title

      J of Berry Res

      Volume: 9 Pages: 1-12

    • DOI

      https://doi.org/10.3233/JBR-180350

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Subthalamic Deep Brain Stimulation on Upper Limb Dexterity in Patients with Parkinson Disease2018

    • Author(s)
      Nozaki T*, Asakawa T*, Sugiyama K, Koda Y, Shimoda A, Mizushima T, Sameshima T, Namba H
    • Journal Title

      World Neurosurg

      Volume: 115 Pages: e206-e217

    • DOI

      https://doi.org/10.1016/j.wneu.2018.04.014

    • Peer Reviewed
  • [Journal Article] Genomic Subtypes of GISTs for Stratifying Patient Response to Sunitinib following Imatinib Resistance: A Pooled Analysis and Systematic Review2018

    • Author(s)
      Tan S, Chen P, Ji J, Guo S, Yu D, Asakawa T, Zhou Y, Abe M, Zong L*
    • Journal Title

      Dis Markers

      Volume: 26 Pages: 1368617

    • DOI

      https://doi.org/10.1155/2018/1368617

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deep Brain Stimulation for Intractable Obsessive-compulsive Disorder: The International and Japanese Situation/Scenario2018

    • Author(s)
      Sugiyama K*, Nozaki T, Asakawa T, Sameshima T, Koizumi S, Hiramatsu H, Namba H
    • Journal Title

      Neurol Med Chir

      Volume: 58 Pages: 369-376

    • DOI

      https://doi.org/10.2176/nmc.st.2018-0115

    • Peer Reviewed
  • [Journal Article] Current behavioral assessments of movement disorders in children2018

    • Author(s)
      Asakawa T*, Sugiyama K, Nozaki T, Sameshima T, Kobayashi S, Wang L, Hong Z, Chen SJ, Li CD, Ding D, Namba H
    • Journal Title

      CNS Neurosci Ther

      Volume: 24 Pages: 863-875

    • DOI

      https://doi.org/10.1111/cns.13036

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature2018

    • Author(s)
      Jiang F, Yang T, Yin H, Guo Y, Namba H, Sun Z, Asakawa T*
    • Journal Title

      Front Neurol

      Volume: 9 Pages: 596

    • DOI

      https://doi.org/10.3389/fneur.2018.00596

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats2018

    • Author(s)
      Liang W, Li X, Li G, Hu L, Ding S, Kang J, Shen J, Li C*. Asakawa T*
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: Aug 26 Pages: 9210490

    • DOI

      https://doi.org/10.1155/2018/9210490

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis, and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An in Vivo Study2018

    • Author(s)
      Li S, Huang M, Chen Q, Li S, Wang X, Lin J, Zhong G, Lin P*, Asakawa T*
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: Sep 26 Pages: 4905089

    • DOI

      https://doi.org/10.1155/2018/4905089

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of Angle in the Evaluation of Ablation Accuracy in Pulmonary Vein Isolation Navigated by Image Integration2018

    • Author(s)
      Song-Wen Chen, Li-Dong Cai, Tetsuya Asakawa*, Gen-Qing Zhou, Yong Wei, Bao-Zhen Qi, Zhi-Yu Ling, Hai-Qing Wu, Juan Xu, Shao-Wen Liu*
    • Journal Title

      The Heart Surgery Forum

      Volume: 21 Pages: E438-E442

    • DOI

      https://doi.org/10.1532/hsf.2231

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Rehabilitation After Stroke, the Viewpoints From Japan2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      the 4th TCM master forum
    • Int'l Joint Research / Invited
  • [Presentation] Current state of TCM in Japan2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th annual meeting of World Federation of Chinese Medicine Societies
    • Int'l Joint Research / Invited
  • [Presentation] The strategy of “Deep Brain Stimulation” for treating Parkinson’s disease in non-human primate animals2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th DBS Think Tank
    • Int'l Joint Research / Invited
  • [Presentation] Principles of OMS during behavioral tests for Parkinson’s disease2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      Workshop for Parkinson’s disease & Movement Disorders
    • Int'l Joint Research / Invited
  • [Presentation] Behavioral tests for Parkinson’s disease2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 1th annual meeting of Chinese Rehabilitation Society for Parkinson’s disease & Movement Disorders
    • Int'l Joint Research / Invited
  • [Presentation] Principles of behavioral tests for symptom evaluation, an example of Parkinson’s disease----insights from animal to human being2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th annual meeting of World Federation of Chinese Medicine Societies
    • Int'l Joint Research / Invited

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Published: 2019-12-27  

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