Analysis of neural plasticity induced by intravenous infusion of mesenchymal stem cells in experimental model of cerebral infarction

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Sapporo Medical University
• Principal Investigator: Hiroshi Nagahama 札幌医科大学, 医学部, 研究員 (20725676)
• Co-Investigator(Kenkyū-buntansha): 鈴木 淳平 札幌医科大学, 医学部, 研究員 (00572596) ; 佐々木 祐典 札幌医科大学, 医学部, 講師 (20538136) ; 中崎 公仁 札幌医科大学, 医学部, 研究員 (70722461) ; 鰐渕 昌彦 札幌医科大学, 医学部, 准教授 (30343388) ; 三上 毅 札幌医科大学, 医学部, 講師 (30372816) ; 小野寺 理恵 札幌医科大学, 医学部, 講師 (60393328) ; 浪岡 隆洋 札幌医科大学, 医学部, 研究員 (70748996) ; 浪岡 愛 札幌医科大学, 医学部, 研究員 (60748995)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経再生 / 骨髄間葉系幹細胞 / 可塑性 / diffusion MRI

Outline of Final Research Achievements

Intravenous infusion of mesenchymal stem cells (MSCs) improves behavioral function in rat stroke models. MRI Diffusion tensor imaging tractography demonstrated that increasedmore “number of tracks” was observed in the MSC-treated group compared to the non-treated group. The number of synaptic puncta in non-infarcted the cortex in the MSC-treated group was higher than the non-treated group. Corpus callosum thickness was greater in the MSC-treated group than the non-treated group. These results suggested enhanced plasticity was occurred following intravenous infusion of MSCs in cerebral infarction. It is conceivable that these processmechanisms might contribute to functional improvement by the infused MSCs in strokefrom cerebral infarction.

Free Research Field

神経再生