Evaluation of Oxidative stress in the brain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: Higuchi Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
• Co-Investigator(Kenkyū-buntansha): 梅田 雅宏 明治国際医療大学, 医学教育研究センター, 教授 (60223608) ; 田中 忠蔵 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541) ; 渡邉 康晴 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; 河合 裕子 明治国際医療大学, 医学教育研究センター, 助教 (90555616) ; 村瀬 智一 明治国際医療大学, 医学教育研究センター, 客員助教 (00708943)
• Research Collaborator: FUKUNAGA Masaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脳代謝 / 酸化ストレス

Outline of Final Research Achievements

Oxidative stress plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. On the other hand, antioxidants such as Glutathione (GSH) is critical for protecting the brain from oxidative stress. It is present in micromolar concentrations in bodily fluids and in millimolar concentrations in tissue. In this study, we will use magnetic resonance spectroscopic imaging to map antioxidants. Magnetic resonance spectroscopic imaging (MRSI) is a noninvasive imaging method and reveals a wealth of metabolic information.

Free Research Field

脳外科