The preventive effect of ursolic acid on the degeneration of rotator cuff muscle

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Gunma University
• Principal Investigator: Takagishi Kenji 群馬大学, 大学院医学系研究科, 名誉教授 (70154763)
• Co-Investigator(Kenkyū-buntansha): 山本 敦史 群馬大学, 大学院医学系研究科, 助教 (30400732) ; 一ノ瀬 剛 群馬大学, 医学部附属病院, 医員 (70742550)
• Co-Investigator(Renkei-kenkyūsha): KOIBUCHI Noriyuki 群馬大学, 大学院医学系研究科, 教授 (80234681)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肩関節 / 腱板断裂 / 骨格筋変性

Outline of Final Research Achievements

We administered ursolic acid, which is reported to have inhibitory effect on atrophy and degeneration of skeletal muscle, to large rotator cuff tear (RCT) rat model. However, we could not find any effect of ursolic acid on our rat model.
Next, we examined a natural course of muscle atrophy in large RCT rat model. We sacrificed the rats at 1, 2, 4, 8,and 16 weeks after the surgery, and collected the supraspinatus (SSP) and infraspinatus (ISP) muscles and weighed it. The weight ratio of SSP muscle significantly reduced at 16 weeks after the surgery than at 1 week, and the weight ratio of ISP muscle significantly reduced at 4 weeks after the surgery than 1 week. These results suggested that the muscle atrophy in large RCT started earlier in ISP muscle than SSP muscle.

Free Research Field

肩関節