The study of aging muscle satellite cell in humans

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: HASHIMOTO Naohiro 国立研究開発法人国立長寿医療研究センター, 再生再建医学研究部, 部長 (00208456)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨格筋 / サルコペニア / 筋分化 / 老化 / 筋細胞 / 不死化 / 酸化ストレス / 細胞周期

Outline of Final Research Achievements

The regenerative capacity of skeletal muscle relies largely on the presence of muscle stem cells, called muscle satellite cells. The capacity for proliferation and/or differentiation of muscle satellite cells is assumed to decline in elderly perspons because the regenerative capacity of muscle decreases during aging. To reveal the age-dependent changes of muscle satellite cells, we have established immortalized human myogenic cell lines derived from muscle satellite cells of young and elderly persons. Immortalized human myogenic cells preserved high capacity for proliferation and/or differentiation independently of the age. The results suggest that the muscle of elderly persons still reserves functional muscle stem cells.

Free Research Field

幹細胞生物学