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2017 Fiscal Year Final Research Report

Effect of synovial mesenchymal stem cells for the rotator cuff healing

Research Project

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Project/Area Number 15K10432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MOCHIZUKI Tomoyuki  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20436637)

Co-Investigator(Kenkyū-buntansha) 関矢 一郎  東京医科歯科大学, 統合研究機構, 教授 (10345291)
二村 昭元  東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座准教授 (40622098)
宗田 大  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50190864)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords再生医療 / 肩腱板断裂 / 滑膜幹細胞
Outline of Final Research Achievements

We performed a research making sure whether cells, harvested from membrane underling joint capsule, enhance rotator cuff healing. We used a rat model and firstly clarified that cells harvested from knee joint is superior to those from shoulder joint in proliferation potential. Secondly we made a rat model with rotator cuff tear on both shoulder and transplanted harvested cells torn site on one shoulder ,and no cells on the other side. We evaluated them on 2, 4 and 8 weeks after transplantation. The shoulders with transplanted cells showed superior to those with no cells in terms of bone-tendon healing in 8 weeks, and biomechanicaly had a higher ultimate load to failure than those without cell transplantation in 2 weeks.

Free Research Field

再生医療、肩関節疾患

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Published: 2019-03-29  

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