Development of fragility fracture treatment using molecular evolution engineering

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Watanabe Noriyuki 岡山大学, 医学部, 客員研究員 (80708107)
• Co-Investigator(Kenkyū-buntansha): 尾崎 敏文 岡山大学, 医歯薬学総合研究科, 教授 (40294459) ; 松川 昭博 岡山大学, 医歯薬学総合研究科, 教授 (90264283)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体材料 / チタン結合性BMP / リン酸化プルラン

Outline of Final Research Achievements

We investigated the availability of a titanium binding bone morphologic protein(TB-BMP), which is a new biological material. TB-BMP coating titanium wires and conventional titanium wires were implanted in the femur of rats. TB-BMP coating titanium wires significantly enhanced bone formation on the surface of titanium compared to conventional titanium wires. Pull-out strength was also significantly increased in TB-BMP group. These results suggest that TB-BMP is a useful material for the treatment for the osteoporotic patients.

Free Research Field

整形外科学