Establishment of early diagnosis and treatment in the patient with the surgical site infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10457
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: International University of Health and Welfare (2017); Keio University (2015-2016)
• Principal Investigator: ISHII KEN 国際医療福祉大学, 医学部, 主任教授 (00276289)
• Co-Investigator(Renkei-kenkyūsha): AIZAWA MAMORU 明治大学, 理工学部, 教授 (10255713) ; OKADA YASUNORI 順天堂大学, 医学部, 客員教授 (00115221)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨軟部組織 / 感染症 / インプラント関連感染症 / メタボローム解析

Outline of Final Research Achievements

Osteomyelitis which is often caused from surgical site infection is a serious problem in orthopedic surgery. Although several candidates of osteomyelitis biomarkers were investigated, potential specific biomarkers for diagnosis of osteomyelitis have not been detected yet. Here, we examined the metabolome analysis (ＣＥ－ＴＯＦＭＳ,ＬＣ－ＴＯＦＭＳ)to detect specific plasma biomarkers of osteomyelitis using mouse osteomyelitis model. 279 metabolites were detected by the metabolome analyses. Principal component analysis showed that both sphingosine and sphinganine were detected as the highest loading factors.

Free Research Field

医歯薬学