2017 Fiscal Year Final Research Report
Development of a suspended synovium culture model mimicking inside of the knee joint
| Project/Area Number |
15K10463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KATANO Hisako 東京医科歯科大学, 統合研究機構, 助教 (50376620)
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| Co-Investigator(Kenkyū-buntansha) |
関矢 一郎 東京医科歯科大学, 統合研究機構, 教授 (10345291)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 再生医療 |
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| Outline of Final Research Achievements |
Drugs that induce mesenchymal stem cells (MSCs) from the synovium can be a promising treatment for mild tissue injury. We developed a suspended synovium culture model. Fibrous synovium was found to release greater numbers of MSCs than adipose synovium. Mobilization of MSCs from the synovium was demonstrated using a suspended synovium culture model in RA. This model can be a valuable tool to screen drugs which induce mobilization of MSCs from the synovium into synovial fluid in the knee joint.
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| Free Research Field |
再生医療
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