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2017 Fiscal Year Final Research Report

Elucidation of osteoporotic pain by a manifestation search of a bone resorption

Research Project

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Project/Area Number 15K10468
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

Wakabayashi Hiroki  三重大学, 医学部附属病院, 講師 (50362687)

Co-Investigator(Kenkyū-buntansha) 加藤 祥  三重大学, 医学系研究科, リサーチアソシエイト (30741152)
須藤 啓広  三重大学, 医学系研究科, 教授 (60196904)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords骨粗鬆症 / 疼痛
Outline of Final Research Achievements

Ovariectomy induced bone loss and mechanical hyperalgesia in hindlimbs with upregulation of TRPV1 and CGRP expressions in DRG neurons innervating hindlimbs. Alendronate or teriparatide prevented ovariectomy-induced bone loss and mechanical hyperalgesia in ovariectomized mouse hindlimbs, and it suppressed upregulation of pain markers (TRPV1 and CGRP expressions).

Free Research Field

整形外科

URL: 

Published: 2019-03-29  

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