2017 Fiscal Year Final Research Report
Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeutics
| Project/Area Number |
15K10523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 茂亮 東海大学, 医学部, 准教授 (30582209)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 感染症 / 敗血症 / マクロファージ / 抗原提示 / 自己免疫疾患 |
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| Outline of Final Research Achievements |
Sepsis in elderly patients is associated initially with severe systemic inflammation, but later followed by immuno-suppressive state, which increases the risk of secondary infection. In this study we investigated the mechanism of sepsis-induced immuno-suppression and, based on the mechanism, aimed to established therapeutic strategy to reinstate impaired immune functions. Analysis of macrophages in mice with sepsis revealed that macrophages shifted to a low bactericidal phenotype (M2 type). Presentation by macrophages to T cells of antigenic peptide derived from phagocytosed bacteria is essential for mounting adaptive immune responses. We have established a screening assay system to select compounds that can facilitate antigenic peptide loading onto macrophages.
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| Free Research Field |
炎症
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