2017 Fiscal Year Final Research Report
Development of a new therapy for different incurable pain by combination multiple pain suppression mechanisms
| Project/Area Number |
15K10559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
NOMURA Yuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 痛み / 難治性疼痛 / 多角的治療 |
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| Outline of Final Research Achievements |
In this project, we studied it for developing a new therapy of incurable neuropathic pain by performing of combination multiple pain suppression mechanisms for different severe neuropathic pain animal models.
We made inflammatory animal models, plantar incision models and nerve ligation models in this study periods. We confirmed that a proper model was finished by a behavior evaluation and performed the study that aimed at the development of the effective expression method of having made siRNA which made expression of the BDNF inhibited more effectively and the endorphin in the cultured cell in particular. We also made the hybrid gene with the NGF gene to make beta endorphine productive cells of the secretor and confirmed expression by ELISA in a cultured cell.
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| Free Research Field |
麻酔科学
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