A comprehensive study of the establishment of urolithiasis prophylaxis from both genetic factors and environmental factors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10626
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Ito Yasunori 名古屋市立大学, 大学院医学研究科, 研究員 (70295608)
• Co-Investigator(Kenkyū-buntansha): 郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047) ; 戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733) ; 安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; 岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 尿路結石 / メタボリックシンドローム / 肥満 / 予防 / PPAR

Outline of Final Research Achievements

We have reported that urolithiasis is similar to the onset mechanism of metabolic syndrome. Therefore, in this research, we pushed through these studies, and aimed at establishing a method for preventing urolithiasis prevention, we conducted research from genetic factors and environmental factors.1. Approach from genetic factors: We have found that nicotinamide nucleotide transhydrogenase (Nnt) gene is one of the factors related to the stone formation from the study between subgenera of the mouse.
2. Approach from environmental factors: PPAR-gamma agonist (thiazolidinedione) was administered to stone model rats. It has been reported that it has an inhibitory effect on the formation of calculus accompanied by an altered expression of adipocytokine. The metabolic syndrome forms urinary stone via oxidative stress elevation.

Free Research Field

泌尿器科学