2017 Fiscal Year Final Research Report
Induction of ovarian granulosa cells from mesenchymal stem cells for investigating the molecular mechanisms of their development.
| Project/Area Number |
15K10654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
谷口 隆信 旭川医科大学, 医学部, 教授 (60217130)
加藤 剛志 旭川医科大学, 医学部, 准教授 (60194833)
宇和田 淳介 旭川医科大学, 医学部, 助教 (70580314)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 顆粒膜細胞 / 幹細胞 / SF-1/Ad4BP |
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| Outline of Final Research Achievements |
Granulosa cells constitute the parts of somatic cells in follicles, and are essential for the development of oocytes. The purpose of this study is to induce granulosa cells from stem cells and precursor cells for revealing the molecular mechanism of their development. We established granulosa-like cells from mesenchymal stem cells and undifferentiated granulosa cell tumor-derived cells by introducing SF-1/Ad4BP. Using these systems, it was revealed the genes involved in the differentiation of granulosa cells, and identified a major androgen in human plasma.
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| Free Research Field |
生殖内分泌
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