Identification of labor-onset related mRNA/microRNA and its clinical significance

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University
• Principal Investigator: MIURA Shoko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00404301)
• Co-Investigator(Kenkyū-buntansha): 三浦 清徳 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Labor / microRNA / plasma / placenta / prediction

Outline of Final Research Achievements

Our study confirmed that C19MC microRNAs express from paternal allele. In addition, our data suggested that circulating level of cell-free miR-518b in maternal plasma is associated with the uterine stimulation. The circulating levels of cell-free C19MC microRNAs in maternal plasma increase as progress of pregnancy, and we could determined their reference values of C19MC microRNA in maternal plasma. Our data showed the possibility that the measurement of circulating C19MC microRNAs in maternal plasma makes it possible to predict the timing of labor-onset and to clarify the pathophysiology of labor-onset.

Free Research Field

産科婦人科学