The immune regulatory activated by Vitamin D has been the novel treatment for recurrent implantation failure and recurrent pregnancy losses

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10685
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: Ota Kuniaki 慶應義塾大学, 医学部(信濃町), 共同研究員 (90424142)
• Co-Investigator(Kenkyū-buntansha): 丸山 哲夫 慶應義塾大学, 医学部, 准教授 (10209702) ; 長島 隆 慶應義塾大学, 医学部, 共同研究員 (40338116)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ビタミンD / テトラメチレンヒドロ葉酸代謝還元酵素 / ホモシステイン / 耐糖能異常 / プレコンセプションケア

Outline of Final Research Achievements

Vitamin D deficiency as the immune regulatory, elevation of homocysteine caused by gene polymorphism of tetramethylene hydrofolate metabolic reductase, impaired glucose tolerance to induce the circumstance of inflammation in vivo were clarified that there is an influence on the reproductive process of implantation and placentation. It is suggested that comprehensive nutritional education centered on vitamin D may be necessary for improving fertility, and it became the basis for the evidence of pre conception care.

Free Research Field

生殖医学、生殖免疫学、内分泌・代謝学