2017 Fiscal Year Final Research Report
The development of tailor-made immunotherapy based on ovarian cancer local immunity analysis
| Project/Area Number |
15K10714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Fujita Health University (2017)
Nagoya University (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梶山 広明 名古屋大学, 医学系研究科, 准教授 (00345886)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腹膜播種 / 癌微小環境 / サイトカイン |
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| Outline of Final Research Achievements |
We aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the promotion of tumor neovascularization and vascular permeability via enhanced VEGF production and loclal immunologic effects. We examined whether a characteristic morphological change in human peritoneal mesothelial cells (HPMCs) was observed in the presence of malignant ascites and tumor-derived TGF-β. We focused on the enhanced production of VEGF in CAMCs and its crucial role in endothelial tube formation. Ｗe found that EOC-derived TGF-β induced typical EMT-like morphological alteration in HPMCs, which was associated with CAMCs. We further discovered that CAMCs play a crucial role in the enhanced VEGF production.Furethermore we showed that IL-33 secretion was elevated in high metastatic cell lines.The novel mechanism of CAMCs as a facilitator of EOC progression and immnunological effect are displayed by microenvironmental cell-to-cell communication.
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| Free Research Field |
婦人科悪性腫瘍
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