Analysis of molecular biological and tumor immunological characteristics of HPV negative cervical adenocarcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10729
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: IWATA Takashi 慶應義塾大学, 医学部(信濃町), 講師 (30296652)
• Co-Investigator(Kenkyū-buntansha): 藤田 知信 慶應義塾大学, 医学部(信濃町), 助教 (20199334) ; 川井田 みほ 慶應義塾大学, 医学部(信濃町), 助教 (30767025)
• Co-Investigator(Renkei-kenkyūsha): KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287) ; KUKIMOTO Iwao 国立感染症研究所, 病原体ゲノム解析研究センター, 室長 (70291127)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HPV陰性子宮頸癌 / 診断 / 胃型腺癌 / 細胞内シグナル

Outline of Final Research Achievements

HPV negative adenocarcinoma accounts for approximately 30% of cervical adenocarcinomas, and the age of onset is older than those with HPV positive cases.FIGO stage of HPV negative adenocarcinom tend to be progressive cases. The majority of HPV negative adenocarcinomas localized in the cervical canal and was difficult to detected by colposcopy. In immunohistochemistry of HIK1083, p53, p16, Ki-67, MUC6 in 20 cases of negative adenocarcinoma, the positive rate was HIK 1083:40%, p53:40%, p16:75%, Ki-67: 50%, MUC6:60%. Immune cell infiltration was not different between positive adenocarcinoma and HPV negative adenocarcinoma in all of CD4, CD8, CD20, FOXP3. As a result of microarray, EIF2 signal was activated in HPV negative adenocarcinoma

Free Research Field

婦人科腫瘍学