Development of new diagnostic and therapeutic biomarkers for cervical adenocarcinoma using high sensitivity sugar chain analysis system

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K10736
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Tozawa-Ono Akiko 聖マリアンナ医科大学, 医学部, 准教授 (90569865)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 子宮頸がん / 子宮頸部腺癌 / 診断キット

Outline of Final Research Achievements

We identified novel marker candidates that could potentially detect cervical adenocarcinoma using high sensitivity lectin microarrays. Currently, candidate lectins are being used to determine which specimens, such as cervical mucus, blood, and the remaining specimens of cytology, are suitable as specimens for examination. At the same time, it is in the way of considering some test methods. We will not refer to any specific content in this report, as we will apply for a patent after establishing a specific inspection method.

Free Research Field

婦人科悪性腫瘍

Academic Significance and Societal Importance of the Research Achievements

子宮頸部腺癌は近年増加傾向で若年の罹患数が増加しており社会的に問題となっている。また子宮頸がん検診は早期発見の方法として科学的根拠のある方法であるが、国内外の研究結果から子宮頸部腺癌は子宮頸がん検診（細胞診）での早期発見、罹患率減少効果が乏しいことが知られている。そこで子宮頸部腺癌検出の新たな方法の開発が必要と考えている。本研究では子宮頸部腺癌検出検査法の開発を主に進めているが、この検査方法が実現すると若年女性の子宮頸部腺癌の早期発見が可能になり、妊孕性温存（子宮温存）が可能になる。