2017 Fiscal Year Final Research Report
The role of HRF in pollinosis
| Project/Area Number |
15K10794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
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| Research Collaborator |
KAWAKAMI Toshiaki 理化学研究所, 統合生命医科学研究センター, チームリーダー (60143418)
ANDO Tomoaki 順天堂大学, 医学研究科, 助教 (10724669)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ヒスタミン遊離因子（HRF) / マスト細胞 / 花粉症 / アレルギー性鼻炎 |
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| Outline of Final Research Achievements |
It is reported that Histamine-Releasing Factor (HRF) binds to a subset of IgE/IgG and is involved in mast cell-dependent allergic reactions. Howevere, it is still unknown whether HRF is involved in other allergic diseases such as pollinosis. The purpose of this study is to investigate the role of HRF in allergic rhinitis/pollinosis. It was shown that only HRF dimer has ability to stimulate HRF-reactive IgE-bound mast cells. Using ragweed pollen-induced pollinosis mouse model, it was observed that HRF treatment inhibited ragweed pollen-induced pollinosis, suggesting that HRF is involved in the allergic rhinitis/pollinosis.
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| Free Research Field |
アレルギー
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