2017 Fiscal Year Final Research Report
Elucidation of the mechanism of effect of REG gene as a biomarker in head and neck cancer
| Project/Area Number |
15K10822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 一郎 奈良県立医科大学, 医学部, 講師 (00326323)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | REG遺伝子 / バイオマーカー / 頭頸部癌 |
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| Outline of Final Research Achievements |
In this study we demonstrated that Regenerating gene III (REG III) expression was such a marker associated with an improved survival rate for HNSCC patients. Moreover, we found that resveratrol (3,4',5-trihydroxy-trans-stilbene) significantly increased the REG III expression in HNSCC cells, and significantly inhibited cell growth, enhanced chemo- and radio-sensitivity, and blocked cancer invasion of HNSCC cells in vitro. We found that resveratrol certainly increased the mRNA level of REG III in vivo with our in vitro observation previously. Moreover, REG III augmented the anti-tumor effect of radiation or cisplatin in vivo, and resveratrol sensitized HNSCC to irradiation and cisplatin in vivo. These data suggested that resveratrol increases the efficacy of cisplatin and irradiation through REG III expression pathway, resulting in decreased tumor growth in treating HNSCC in vivo.
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| Free Research Field |
耳鼻咽喉科
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