Actin cytoskeleton control by a HNSCC stem cell marker CD271

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Matsuura Kazuto 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
• Co-Investigator(Kenkyū-buntansha): 田中 伸幸 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 頭頸部癌 / 癌幹細胞

Outline of Final Research Achievements

CD271 is a candidate cancer stem cell marker for HNSCC, but its functional role is left undetermined. By a co-purificaton approach, we identified Cortactin as a binding partner. CD271 positive cells expressed Cortactin, and cortactin-low cells showed decreased tumorigenesis and motility, which is similar to the CD271-loss phenotypes. Notably, actin network was damaged in cortactin-low cells. These results suggest CD271 and cortactin are potential therapeutic targets of head and neck cancer.

Free Research Field

頭頸部外科学