Polyamine metabolism in diabetic retinopathy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: Noda Kousuke 北海道大学, 医学研究院, 准教授 (90296666)
• Co-Investigator(Kenkyū-buntansha): 神田 敦宏 北海道大学, 医学研究院, 特任講師 (80342707)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病網膜症 / ポリアミン / 酸化ストレス

Outline of Final Research Achievements

Recently, the roles of endogenous substance polyamines and its metabolizing enzymes have been focused on in the pathogenesis of systemic diseases such as diabetes. In the current study, we investigated the production mechanism of polyamine-metabolizing enzymes under diabetic condition. Hypoxia induces the production of spermine oxidase (SMOX), and subsequently increases the generation of hydrogen peroxide and acrolein, oxidative stress inducer and unsaturated aldehyde, respectively, through the metabolic reaction of spermine by SMOX in cultured retinal glial cells. The current data indicate that SMOX plays a role in the oxidative stress increase exacerbated under hypoxic condition in diabetic retinopathy.

Free Research Field

眼科学